Complete Precocious Puberty In isosexual precocious puberty, activation of the hypothalamo–pituitary–gonadal axis is similar to that described from normal puberty but occurs at a much earlier age. See later: • Physiology of Complete Precocious Puberty • Idiopathic Precocious Puberty • Central Nervous System Tumours • Hamartomas of the Tuber Cinereum • Neurofibromatosis Type I (von Recklinghausen's disease) • Precocious Puberty – Congenital Adrenal Hyperplasia